| Week One | Line/Score | MVP |
| Redskins @ Seahawks | 24-13 | James Stewart |
| Ravens @ Chiefs | 10-42 | James Allen |
| Giants @ Chargers | 23-7 | Duante Culpepper |
| Bears @ Jets | 24-7 | Marco Coleman |
| Bucs @ Dolphins | 6-38 | Priest Holmes |
| Lions @ Patriots | 19-35 | Lavernius Coles |
| Packers @ Colts | 14-38 | Trent Dilfer |
| Saints @ Jaguars | -3 | |
| Cardinals @ Steelers | 7-10 | Garrison Hearst |
| 49ers @ Browns | 24-40 | Marshall Faulk |
| Rams @ Bengals | 28-64 | Zack Bronson |
| Game of the Week | Line/Score | MVP |
| Cowboys @ Raiders | 32-24 | Shaun Alexander |